Versatile Antimicrobial Technology

“FiteBac®” is a versatile antimicrobial technology, developed by Dr. Kirk Kimmerling and Dr. Franklin Tay, in collaboration with researchers from around the world, allowing for the incorporation of antimicrobial protection into almost any material.

By linking potent quaternary ammonium antimicrobials to a polymerizable silane backbone, they have developed a versatile new class of antimicrobial compounds which can be permanently incorporated into most materials.

K18 QAMS

  • FiteBac® K18 QAMS is a well known Si-Quat biocide covalently bound to a silane core containing acrylate functionality
    • Acrylate functionality allows for co-polymerization within several polymer systems
  • Antimicrobial does not migrate from the polymer
    • Normal wear of a dental device exposes fresh K18 QAMS creating continuous microbiological protection
  • K18 QAMS has been Cleared in a FDA Dental Device
  • Patent protection until 2033

K18 QAMS in an FDA 510(k) Cleared Antimicrobial MMA/PMMA Acrylic Resin System. The addition of K18 QAMS to a MMA/PMMA acrylic resin has been shown to improve fracture toughness without adversely affecting flexural modulus and strength of the orthodontic acrylic. (1)

In vitro studies, performed by Dr. Frank Tay, Dental College of Georgia at Augusta University, of orthodontic acrylic resins containing 4–6% K18 QAMS have been shown to possess both in vitro immediate diffusional as well as contact-killing antimicrobial properties when tested with Streptococcus mutans, Actinomyces naeslundii and Candida albicans. (1)

(1) Gong, et.al ‘An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties’, PLoS one, (2012) Vol 7 (8)

K21 QAMS

  • FiteBac® K21 QAS, consists of four Silane Quaternary Ammonium structures 
    covalently linked to a silane core
  • Studies have shown that K21 QAS demonstrates
    • Does not negatively impact adhesive bond strength to dentin (1,2)
    • Excellent antimicrobial activity (1,3)
    • Improves infiltration of adhesive monomers into acid etched dentin (1)
    • Inhibition of MMP-9 and Cathepsin-K (1,3)
  • Patent Protection until 2033
  1. Gou, YP et.al. “Quaternary ammonium silane-based antibacterial and anti-proteolytic cavity cleanser”, Dental Mat., (34), 2018 pgs 1814-1827.
  2. Daood, D. et.al “Effect of a novel quaternary ammonium silane cavity disinfectant on durability of resin-dentine bond”, J Dent (60) 2017 pgs 77-86.
  3. Umer, D. etr.al. “Effect of a novel quaternary ammonium silane on dentin protease activities”, J Dentistry, J. Dent (58) 2017 pgs 19-27

Biofilm Video

Video Explanation:

Example of plaque biofilms containing mixed bacterial-fungal components.

(a) BacLightstained CLSM merged image showing the presence of live (green) fungal hyphae (open arrowhead) within the biovolume of a biofilm taken from a control disk of one subject (subject 21).

(b) The corresponding BacLightstained CLSM merged image showing the presence of dead (red) fungal hyphae killed by the QAMS-containing acrylic (open arrowhead) from an experimental disk of the same subject.